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Immunohistochemical Features. The left panel shows the cutaneous group, specifically from the shoulder skin, and the right panel shows the visceral group, specifically from an inguinal lymph node. Both panels display the immunohistochemical expression of PD-1, PD-L1, CyclinD1, RB, and BCL-2. Among these, PD-1 showed positivity in lymphocytes within the tumor stroma; PD-L1 showed membrane positivity in tumor cells; CyclinD1 and RB showed nuclear positivity; and BCL-2 showed cytoplasmic positivity

Journal: BMC Cancer

Article Title: Comparative study of clinical features, pathology, and immunophenotype between HIV-related cutaneous and visceral Kaposi’s sarcoma

doi: 10.1186/s12885-026-15910-w

Figure Lengend Snippet: Immunohistochemical Features. The left panel shows the cutaneous group, specifically from the shoulder skin, and the right panel shows the visceral group, specifically from an inguinal lymph node. Both panels display the immunohistochemical expression of PD-1, PD-L1, CyclinD1, RB, and BCL-2. Among these, PD-1 showed positivity in lymphocytes within the tumor stroma; PD-L1 showed membrane positivity in tumor cells; CyclinD1 and RB showed nuclear positivity; and BCL-2 showed cytoplasmic positivity

Article Snippet: Sections were incubated with rabbit anti-human antibodies against CyclinD1 (SP4), Rb (13A10), BCL-2 (124), P53 (BP-53-12), PD-1 ((2E5), PD-L1 (ZR3), Ki-67 (MIB-1), and, CD34 (QBEnd10) (from Gene Tech, Shanghai, China), HHV8 (13B10) (from zsbio, Beijing, China) for 25 min at room temperature.

Techniques: Immunohistochemical staining, Expressing, Membrane